Research project

paraQchip - Parahydrogen-Induced Hyperpolarisation On A Chip For Microfluidic Perfusion Culture

Research groups:

Organic Chemistry, Synthesis, Catalysis
Lead researcher:

Professor Marcel Utz
Other researchers:

Professor Richard Whitby,

Professor Malcolm Levitt,

Professor Ilya Kuprov
Research funder:

EPSRC
Status:

Active

Staff

Lead researcher

Professor Marcel Utz

Professorial Fellow-Research

Research interests

Integration of microfluidic lab-on-a-chip technology with NMR spectroscopy and imaging;
Behaviour of complex materials.

Connect with Marcel

Email: Marcel.Utz@soton.ac.uk

Other researchers

Professor Richard Whitby

Professor of Chemistry

Research interests

Synthesis, properties and application of atomic and molecular endofullerenes.
The use of flow chemistry for the rapid acquisition of mechanistic and process information.
The synthesis of polyaromatic molecules for optoelectronic applications.

Connect with Richard

Email: R.J.Whitby@soton.ac.uk

Professor Malcolm Levitt

Professor of Chemistry

Research interests

Magnetic Resonance
Endofullerenes

Connect with Malcolm

Email: mhl@soton.ac.uk

Professor Ilya Kuprov FRSC

Professor of Physics

Connect with Ilya

Email: i.kuprov@soton.ac.uk

Collaborating research institutes, centres and groups

Magnetic Resonance

Our main focus is finding ways to extend the timescale over which magnetic resonance can be made.

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Quantitative analysis of 2D EXSY NMR spectra of strongly coupled spin systems in transmembrane exchange

Dmitry Shishmarev, Clement Q. Fontenelle, Bruno Linclau, Ilya Kuprov & Philip W. Kuchel, 2023, ChemBioChem, e202300597

DOI: 10.1002/cbic.202300597

Type: article

Simulation and design of shaped pulses beyond the piecewise-constant approximation

Uluk Rasulov, Anupama Acharya, Marina Carravetta, Guinevere Mathies & Ilya Kuprov, 2023, Journal of Magnetic Resonance, 353

DOI: 10.1016/j.jmr.2023.107478

Type: article

Operando NMR metabolomics of a microfluidic cell culture

Genevieve Alice Rogers, Sylwia Ostrowska, Manvendra Sharma, Salim Khakoo & Marcel Utz, 2023, Journal of Magnetic Resonance, 349

DOI: 10.1016/j.jmr.2023.107405

Type: article

Theory and simulation framework for the relaxation of nuclear spin order in porous media

Topaz A. A. Cartlidge, Thomas B. R. Robertson, Marcel Utz & Giuseppe Pileio, 2022, The Journal of Physical Chemistry B, 126(34), 6536-6546

DOI: 10.1021/acs.jpcb.2c03575

Type: article

Fully automated characterization of protein-peptide binding by microfluidic 2D NMR

Marek Plata, Manvendra Sharma, Marcel Utz & Jörn M. Werner, 2022, Journal of the American Chemical Society, 145(5), 3204–3210

DOI: 10.1021/jacs.2c13052

Type: article